The Panthers vs 49ers matchup has been closely contested historically, with the Carolina Panthers leading the overall series 13–11 after 24 meetings, including one playoff game. In the most recent meeting, however, the San Francisco 49ers defeated Carolina 20–9 on November 24, 2025 at Levi’s Stadium.
The 2025 game was controlled largely by San Francisco’s defense, rushing attack, and time of possession. The 49ers gained 340 total yards and held the ball for 37:42, while Carolina managed 230 yards and 22:18 of possession. Christian McCaffrey rushed for 89 yards and a touchdown, while Brock Purdy threw for 193 yards and one touchdown despite three interceptions. Bryce Young passed for 169 yards, one touchdown and two interceptions.
Quick Answer
The Carolina Panthers lead the Panthers vs 49ers all-time series 13–11, including a 13–10 regular season advantage and a 0–1 playoff record. The 49ers won the latest meeting 20–9 on November 24, 2025, extending their recent winning streak against Carolina to three games.
Why People Compare the Panthers and 49ers
The Panthers and 49ers are both NFC teams, but they play in different divisions.
- Carolina Panthers: NFC South
- San Francisco 49ers: NFC West
- Total meetings: 24
- Panthers overall wins: 13
- 49ers overall wins: 11
- Regular-season record: Panthers lead 13–10
- Playoff record: 49ers lead 1–0
- Latest winner: San Francisco 49ers
- Latest score: 49ers 20 Panthers 9
- Latest meeting: November 24, 2025
Although Carolina leads the overall series, San Francisco has dominated the most recent meetings. The 49ers won in 2019, 2022 and 2025.
First Team: Carolina Panthers
The Carolina Panthers are an NFC South team based in Charlotte, North Carolina.
Carolina has won 13 of the 24 meetings against San Francisco. The Panthers’ advantage is mainly built from their regular season record, where they lead the 49ers 13–10.
Panthers vs 49ers Record
The historical matchup record for Carolina includes:
- Total meetings: 24
- Panthers wins: 13
- Panthers losses: 11
- Regular-season record: 13–10
- Playoff record: 0–1
- Latest result: Loss, 9–20
- Total Panthers points in the series: 554
- Total 49ers points in the series: 534
Carolina’s largest recent victory over San Francisco came in 2016, when the Panthers won 46–27. The Panthers also defeated the 49ers 23–3 in 2017.
Second Team: San Francisco 49ers
The San Francisco 49ers are an NFC West team based in Santa Clara, California.
San Francisco trails Carolina 11–13 in the overall series, but the 49ers have controlled the matchup in recent years. They won the last three regular-season meetings, including victories in 2019, 2022, and 2025.
The 49ers also own the only postseason victory between the teams. San Francisco defeated Carolina 23–10 in the 2013 NFC Divisional Round.
Panthers vs 49ers Comparison Table
| Statistic | Carolina Panthers | San Francisco 49ers |
|---|---|---|
| Total meetings | 24 | 24 |
| Overall wins | 13 | 11 |
| Overall losses | 11 | 13 |
| Regular-season wins | 13 | 10 |
| Regular-season losses | 10 | 13 |
| Playoff wins | 0 | 1 |
| Playoff losses | 1 | 0 |
| Latest result | Lost 9–20 | Won 20–9 |
| Latest meeting | Nov. 24, 2025 | Nov. 24, 2025 |
| 2025 total yards | 230 | 340 |
| 2025 possession | 22:18 | 37:42 |
| 2025 rushing attempts | 13 | 38 |
| Conference | NFC | NFC |
| Division | NFC South | NFC West |
The historical series figures are based on all 24 meetings, while the game statistics refer to the November 24, 2025 matchup.
When to Use Each Statistic
Different Panthers vs 49ers statistics answer different questions about the matchup.
Use the Overall Record for Historical Context
The overall record shows the complete history between the teams.
The Panthers currently lead 13–11 after 24 meetings.
Use the Regular Season Record for NFL Matchups
If you are interested only in regular season games, Carolina leads 13–10.
Use the Playoff Record for Postseason History
The playoff record tells a different story.
San Francisco is 1–0 against Carolina in postseason meetings, with the 49ers winning the 2013 NFC Divisional Round 23–10.
Use Recent Results for Current Rivalry Trends
Recent games are useful for understanding which team has controlled the matchup lately.
San Francisco won the 2019, 2022 and 2025 meetings.
10+ Key Panthers vs 49ers Stats and Facts
1. Carolina Leads the Overall Series
The Panthers have won 13 of 24 total meetings, while San Francisco has won 11.
2. Carolina Also Leads the Regular Season
The Panthers have a 13–10 regular-season advantage over the 49ers.
3. San Francisco Leads the Playoff Series
The 49ers are 1–0 in postseason meetings against Carolina.
4. San Francisco Won the Latest Game
The 49ers defeated the Panthers 20–9 on November 24, 2025.
5. The 49ers Had More Total Yards
San Francisco produced 340 total yards, compared with Carolina’s 230.
6. San Francisco Dominated Time of Possession
The 49ers controlled the ball for 37:42, while Carolina had possession for only 22:18.
7. Christian McCaffrey Led the 49ers’ Rushing Attack
McCaffrey carried the ball 24 times for 89 yards and one touchdown in the 2025 matchup.
8. Brock Purdy Passed for 193 Yards
Purdy completed 23 of 32 passes for 193 yards and one touchdown, but he also threw three interceptions.
9. Bryce Young Passed for 169 Yards
Young completed 18 of 29 passes for 169 yards and one touchdown, with two interceptions.
10. The 49ers Ran 38 Times
San Francisco used a run-heavy offensive approach, recording 38 rushing attempts compared with Carolina’s 13.
11. Carolina Scored Only Nine Points
The Panthers scored a field goal in the second quarter and a touchdown in the third, but they were shut out in the first and fourth quarters.
12. San Francisco Scored in Every Quarter
The 49ers scored seven points in the first quarter, three in the second, seven in the third, and three in the fourth.
13. The 2019 Meeting Was a Blowout
San Francisco defeated Carolina 51–13 on October 27, 2019.
14. The 2022 Meeting Also Favored San Francisco
The 49ers defeated the Panthers 37–15 on October 9, 2022.
15. Carolina Had a Strong Run in 2016–2017
The Panthers defeated San Francisco 46–27 in 2016 and 23–3 in 2017.
Common Mistakes When Reading Panthers vs 49ers Stats
Mistake 1: Saying the 49ers Lead the Overall Series
San Francisco has won the most recent three meetings, but Carolina still leads the overall series 13–11.
Mistake 2: Forgetting the Playoff Meeting
The teams have played one postseason game. San Francisco won that game 23–10 in the 2013 NFC Divisional Round.
Mistake 3: Looking Only at Recent Results
The 49ers have dominated the recent matchup, but the complete history still favors Carolina.
Mistake 4: Looking Only at Passing Yards
In the 2025 game, neither quarterback had a huge passing total. The bigger difference was San Francisco’s ability to control the ball and generate 340 total yards.
Mistake 5: Ignoring Time of Possession
The 49ers held the ball for more than 37 minutes, giving their offense significantly more opportunities than Carolina’s offense.
Memory Trick
Use this simple formula:
Overall: Panthers 13 – 49ers 11
Then remember:
Playoffs: 49ers 1 – Panthers 0
For the latest game:
49ers 20 – Panthers 9
A useful sentence to remember is:
Carolina leads the history, but San Francisco owns the recent matchup.
American vs British English
The Panthers vs 49ers matchup uses standard American football terminology.
Common NFL terms include:
- Football — American football in the United States
- Touchdown — a six-point scoring play
- Rushing — running with the ball
- Passing — throwing the ball
- Interception — a defensive player catches a pass intended for the offense
- Field goal — a kick through the goalposts
- Yard — standard NFL distance measurement
- Possession — the period when a team controls the ball
In British English, the word football generally refers to association football, which Americans usually call soccer.
Similar NFL Matchups
Readers interested in the Panthers vs 49ers matchup may also compare:
- Panthers vs Saints
- Panthers vs Falcons
- Panthers vs Buccaneers
- 49ers vs Seahawks
- 49ers vs Rams
- 49ers vs Cardinals
Useful statistics for these comparisons include:
- Head-to-head record
- Regular-season record
- Playoff record
- Recent results
- Total yards
- Passing yards
- Rushing yards
- Turnovers
- Time of possession
- Points scored
- Points allowed
Final Verdict
The Panthers vs 49ers overall series currently favors Carolina, with the Panthers holding a 13–11 advantage after 24 meetings. Carolina also leads the regular-season series 13–10 but San Francisco owns the only playoff victory between the teams.
The latest meeting tells a different story. San Francisco defeated Carolina 20–9 on November 24, 2025, controlling possession and total yardage while limiting the Panthers to 230 yards. The 49ers’ recent victories in 2019, 2022 and 2025 show that recent form does not always match the all time record.
FAQs
Who has the better Panthers vs 49ers record?
The Carolina Panthers lead the overall series 13–11 after 24 meetings.
Who won the latest Panthers vs 49ers game?
The San Francisco 49ers won the latest meeting 20–9 on November 24, 2025.
Who leads the Panthers vs 49ers regular season series?
The Panthers lead the regular-season series 13–10.
Who leads the Panthers vs 49ers playoff series?
The San Francisco 49ers lead the playoff series 1–0. They defeated Carolina 23–10 in the 2013 NFC Divisional Round.
How many times have the Panthers and 49ers played?
The Panthers and 49ers have played 24 total games, including 23 regular season meetings and one playoff game.
What was the Panthers vs 49ers score in 2025?
The 49ers defeated the Panthers 20–9 on November 24, 2025 at Levi’s Stadium.
Who had more total yards in the latest Panthers vs 49ers game?
San Francisco had 340 total yards, while Carolina had 230 total yards.
Who scored a touchdown for the 49ers in the latest game?
Christian McCaffrey scored a rushing touchdown, while Jauan Jennings caught a touchdown pass from Brock Purdy in the 2025 meeting.
Remember This
The most important Panthers vs 49ers facts are:
- Overall series: Panthers lead 13–11
- Total meetings: 24
- Regular-season series: Panthers lead 13–10
- Playoff series: 49ers lead 1–0
- Latest winner: San Francisco 49ers
- Latest score: 49ers 20, Panthers 9
- Latest meeting: November 24, 2025
- 2025 total yards: 49ers 340, Panthers 230
- 2025 possession: 49ers 37:42, Panthers 22:18
- 2025 rushing attempts: 49ers 38, Panthers 13
Conclusion
The Panthers vs 49ers matchup has a fascinating split between historical and recent results. Carolina leads the overall series 13–11 and the regular season series 13–10 but San Francisco has won the last three meetings and owns the only playoff victory between the teams.
The 2025 game was a clear example of San Francisco’s control. The 49ers produced 340 yards, held possession for nearly 38 minutes and scored in every quarter. Carolina managed only nine points, allowing San Francisco to secure a 20–9 victory and add another win to its recent run against the Panthers.
